Role of a Novel Family of Short RNAs, tRFs, in Prostate Cancer

Abstract

tRFs are precisely generated fragments of tRNA which are shown to function by associating to Argonaute proteins. Unlike microRNA, the biogenesis of tRFs is independent of Dicer and Drosha enzymes. Upon meta-analysis of more than 50 small RNA-seq data of different species and cell lines we have previously shown the presence of fragments generated from both 5 and 3 end of the tRNA and called them as tRF-5 and tRF-3, respectively. We are now interested in mining TCGA prostate cancer patients data to identify tRFs and predict potential targets involved in prostate cancer cell migration and proliferation.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2017
Accession Number
AD1050231

Entities

People

  • Manjari Kiran

Tags

DTIC Thesaurus Topics

  • Biological Markers
  • Biomedical Research
  • Cancer
  • Cell Line
  • Cells
  • Data Analysis
  • Data Mining
  • Data Processing
  • Diseases And Disorders
  • Electronic Mail
  • Genetics
  • Migration
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Trna
  • United States

Fields of Study

  • Biology

Readers

  • Logistics and Supply Chain Management.
  • Molecular and genetic basis of cancer.