Grandparental Exposures and Risk of Autism in the Third Generation
Abstract
In the first year, we have successfully completed the first milestones of this project: getting institutional, state and federal IRB approval for this study and acquiring California Birth Records (1975-2014) for linkage to the Child Health and Development Studies (CHDS). We are developing and refining a matching procedure to optimize the identification of the third generation (F2) of CHDS births. To test our matching criteria and protocols, we ran a pilot match using 1994, which was one of the birth years predicted to include a maximum of CHDS births. The results of the pilot show that we identified approximately 800 matches for our F1 females, which reflect our initial prediction. Because the birth record variables available for matching change year by year, each year will potentially require its own matching criteria. We are continuing to refine the matching protocol for other years and for our F! males. This will be the first study of its kind in the United States, linking three generations from the 1960's through the 2010's and will establish a platform for studying germline exposures and risk of autism.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2017
- Accession Number
- AD1050356
Entities
People
- Barbara A Cohn
- Nickilou Krigbaum
- Piera Cirillo
Organizations
- Public Health Institute