Synthetic Lethal Metabolic Targeting of Senescent Cells After Androgen Deprivation Therapy

Abstract

Progression to castrate resistant prostate cancer for men with advanced prostate cancer (PC) results after the initiation of androgen deprivation therapy (ADT). One underutilized therapeutic strategy that has the potential to dramatically improve outcomes is eradicating the persistent cancer cells that remain after ADT and likely play a key role in the development of castration-resistant PC. The initiation of ADT induces susceptibilities in PC cells that make them amenable to synergistic treatment and improved cell killing.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2017
Accession Number
AD1050370

Entities

People

  • David F Jarrard

Organizations

  • University of Wisconsin–Madison

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Androgens
  • Apoptosis
  • Breast Cancer
  • Cancer
  • Castration
  • Cell Physiological Processes
  • Culture Techniques
  • Department Of Veterans Affairs
  • Diseases And Disorders
  • Mammary Glands
  • Medical Personnel
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Therapy
  • Tissues

Readers

  • Prostate Cancer Biology.