Synthetic Lethal Metabolic Targeting of Senescent Cells after Androgen Deprivation Therapy

Abstract

Progression to castrate resistant prostate cancer for men with advanced prostate cancer (PC) results after the initiation of androgen deprivation therapy (ADT). Oneunderutilized therapeutic strategy that has the potential to dramatically improve outcomes is eradicating the persistent cancer cells that remain after ADT and likely play a key role in the development of castration-resistant PC. The initiation of ADT induces susceptibilities in PC cells that make them amenable to synergistic treatment and improved cell killing.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2017
Accession Number
AD1050371

Entities

People

  • Vincent Cryns

Organizations

  • University of Wisconsin System

Tags

DTIC Thesaurus Topics

  • Androgens
  • Apoptosis
  • Breast Cancer
  • Cancer
  • Castration
  • Cell Line
  • Cell Physiological Processes
  • Clinical Trials
  • Department Of Veterans Affairs
  • Deprivation
  • Diseases And Disorders
  • Mammary Glands
  • Medical Personnel
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Therapy

Readers

  • Prostate Cancer Biology.