Cortical Photostimulation Technology for Vision Prosthesis
Abstract
The overall goal of the project is to evaluate the feasibility of using photochemical stimulation of cortical neurons as the basis for a visual prosthesis. The most significant result from this reporting period is the successful synthesis of a caged glutamate. Caged glutamates are biological inert molecules that, upon exposure to a focused flash of light, are rapidly transformed into the bioactive neurotransmitter, glutamate, which can directly stimulate cortical neurons. The new caged molecule has an absorption peak in the visible wavelength range, at 458 nm this exceeds the original expectation of absorption peaking at ~410 nm.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2017
- Accession Number
- AD1050426
Entities
People
- Joseph P. Kao
Organizations
- University of Maryland