Application of Combined Cardioprotective Agents to Preserve Organ Function and Improve Survival during Experimental Hemorrhagic Shock
Abstract
Hemorrhagic shock remains a major cause of mortality and morbidity on the battlefield and in the civilian world after trauma and accidents. Even with restoration of blood volume, organs subjected to hemorrhagic shock can develop ischemia/reperfusion injury and fail. The overall purpose of these studies is to develop novel therapies to improve survival and organ function in the setting of hemorrhagic shock and consider combinations of therapies. So far we have developed a model of experimental shock that simulates blood loss followed by blood return on the battlefield. Early studies suggest that the anesthetic agent isoflurane improved survival and improved recovery of blood pressure. Remote ischemic preconditioning, which can be achieved with inflation and deflation of blood pressure cuffs on the limbs also looks promising and may improve survival, reduces lactate level and improves reticulocyte counts.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2017
- Accession Number
- AD1050435
Entities
People
- Robert A Kloner
Organizations
- Huntington Medical Research Institutes