A Novel Perfusion System for Damage Control of Hyperkalemia in Swine (Sus scrofa)
Abstract
Objectives: The standard of care for refractory hyperkalemia is renal replacement therapy (RRT). However, traditional RRT is poorly suited for austere environments. We hypothesized that a simplified hemoperfusion system could control serum potassium concentration in a swine model of acute hyperkalemia. Methods: Ten pigs were anesthetized and instrumented. Following bilateral nephrectomy, animals received intravenous potassium chloride and were randomized to the control or treatment group. In both groups, blood was pumped through an extracorporeal circuit (EC) with an in-line hemodialyzer. In the treatment arm, ultrafiltrate from the hemodialyzer was diverted through cartridges containing novel potassium binding beads and returned to the EC. Results: Serum potassium concentration was significantly lower in the treatment than in the control group over time (P = 0.02). There was no difference in serum total calcium concentration for group or time (P = 0.13 and 0.44, respectively) or platelet count between groups or over time (P = 0.28 and 1.00, respectively). All animals survived until end of experiment. Conclusion: A simplified hemoperfusion system removed potassium in a porcine model. In austere settings, this system could be used to temporize patients with hyperkalemia until evacuation to a facility with traditional RRT.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 20, 2018
- Accession Number
- AD1050693
Entities
People
- Ian J Stewart
Organizations
- David Grant USAF Medical Center