Validation of Functional Reaching Volume as an Outcome Measure across the Spectrum of Abilities in Muscular Dystrophy
Abstract
ACTIVE measures functional reaching volume using the Microsoft Kinect camera while the participant plays an interactive video game regardless of ambulatory status. The objective of this project is to produce a trial ready outcome measure that will enable clinical trials to recruit subjects with a wider range of physical abilities and ages and address the limitation in current Duchenne muscular dystrophy outcomes. The specific aims were designed to improve the current ACTIVE system, determine the utility of integrating wireless motion sensors called Solitons into ACTIVE, and quantify the natural rate of change in FRV and determine the minimal clinically important difference (MCID). A comparison of ACTIVE and Solitons to the gold standard Vicon motion capture system showed the current ACTIVE system is more valid and reliable at the present time. Subject recruitment and data collection in ACTIVE is ongoing, including cross sectional and longitudinal data points in boys with DMD. Additionally, refinement of the Soliton software is underway to reassess the utility of Solitons in conjunction with ACTIVE.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2017
- Accession Number
- AD1050815
Entities
People
- Linda Lowes
- Lindsay Alfano