Quantitative PET Imaging with Novel HER3 Targeted Peptides Selected by Phage Display to Predict Androgen Independent Prostate Cancer Progression

Abstract

Funding from this award has permitted the development of a highly specific peptide that targets HER3 for prostate cancer imaging. The peptide was labeled with a PET imaging radionuclide and injected into mice bearing human prostate cancer. The peptide accumulated at high levels in the tumors, and excisional analysis revealed quantitative accumulation of the peptide in tumors that was linearly correlated with HER3 levels. Biodistribution analysis revealed low off-target accumulation and rapid clearance through the renal system, consistent with small peptides. The peptide represents a promising clinical lead for HER3 imaging in patients with castration resistant prostate cancer.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2017
Accession Number
AD1050824

Entities

People

  • Benjamin Larimer

Organizations

  • Massachusetts General Hospital

Tags

DTIC Thesaurus Topics

  • Acquisition
  • Albumins
  • Amino Acids
  • Androgen Receptors
  • Breast Cancer
  • Cancer
  • Castration
  • Cell Line
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Clearances
  • Clinical Trials
  • Detection
  • Growth Factors
  • Health Services
  • Liquid Chromatography
  • Massachusetts
  • Measurement
  • Molecules
  • Neoplasms
  • Peptide Growth Factors
  • Peptides
  • Positron Emissions
  • Prostate
  • Prostate Cancer
  • Proteins
  • Standards
  • Therapy
  • Tissues

Fields of Study

  • Physics

Readers

  • Molecular Genetics
  • Oncology and Biomarker-Based Cancer Detection.
  • Prostate Cancer Biology.