Blast Induced Thresholds for Neuronal Networks (BITNeT)
Abstract
Connecting the human brain response to blast loading across multiple length scales from synapses through to circuit pathways and neurobehavior remains a key challenge for developing countermeasures to limit the effects of blast in the military. Our MURI intends to help fill this gap by conducting a series of experiments connecting cell, tissue, and animal responses, developing scaling rules to predict the human experience. We examine circuits constructed in vitro and in vivo, and assess the effect of blast-induced circuit changes on the subsequent neurological impairment. We recruited and collaborate with experts in each of the necessary knowledge domains to solve the complex problem of neuronal activation, injury, and tolerance to primary blast injury.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 19, 2017
- Accession Number
- AD1051075
Entities
People
- Barclay Morrison
- Dale Bass
- David F Meaney
- Ted Abel
Organizations
- University of Pennsylvania