Early Identification of Molecular Predictors of Heterotopic Ossification Following Extremity Blast Injury with a Biomarker Assay

Abstract

The purpose of this project is to identify predictive markers of heterotopic ossification in an established animal model that would forecast development of heterotopic ossification (HO) in humans soon after injury. Blast procedures have been completed on all 30 animals (Groups I and II) in the year 1 SOW and 45 animals (Groups III V) in the year 2 SOW. All animals were biopsied and have been sacrificed according to protocol schedule. Groups I and II animals were also followed with scheduled routine radiographs to monitor progression of HO. Specimen samples were analyzed for gene and protein level expression with the Nesti partnering molecular biology lab. Early-appearing gene and protein biomarkers were identified by correlation between animals exhibiting radiographic evidence of HO.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2018
Accession Number
AD1051137

Entities

People

  • Leon Nesti

Organizations

  • Henry M. Jackson Foundation for the Advancement of Military Medicine

Tags

DTIC Thesaurus Topics

  • Amputation
  • Biological Markers
  • Biomedical Research
  • Blast Injuries
  • Data Analysis
  • Diseases And Disorders
  • Gene Expression
  • Heterotopic Ossification
  • Identification
  • Institutional Review Board
  • Local Governments
  • Medical Personnel
  • Military Medicine
  • Osteogenesis
  • Residual Limbs
  • Surgical Amputations
  • Wound Healing

Fields of Study

  • Biology

Readers

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