Local Blockade of CCL21 and CXCL13 Signaling as a New Strategy to Prevent and Treat Osteoarthritis
Abstract
Osteoarthritis (OA) is characterized by progressive cartilage loss, with resultant joint pain that worsens over time. In the present study, we proposed to analyze the role of two chemokines, CCL21 and CXCL13, on OA development caused by partial medial meniscectomy (MMD). A novel hypothesis will be tested that local blockade of the function of CCL21 and CXCL13 at the knee joint will reduce inflammatory cells recruitment and prevent osteoarthritis development. Our first evaluation of the whole knee post-MMD was reported in our first annual report.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2017
- Accession Number
- AD1051155
Entities
People
- Bouchra Edderkaoui