Further Development of an Exhaled microRNA Biomarker of Lung Cancer Risk

Abstract

We seek to devise a non-invasive airway based exhaled microRNA metric for lung cancer risk, initial work to be tested in a case control study. We expanded the microRNA panel to ~30microRNAs, and expanded the cohort beyond Einstein-Montefiore/Bronx to include Bronx /J Peters VAH clinic-based recruits, in a case-control study. We also expanded the assessment of lung cancer subjects to also include limited (3-month) prospective follow-up of non-cancer controls in order to minimize control contamination/misclassification, and improved matching on age, smoking status, and underlying COPD (initial n~90 versus n~90 controls). In essence we were able to detect a discriminant signature from exhaled microRNAs, whereby discriminant accuracy over and above clinical criteria alone, was improved by 3-8.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2017
Accession Number
AD1051161

Entities

People

  • Simon D Spivack

Organizations

  • Albert Einstein College of Medicine

Tags

DTIC Thesaurus Topics

  • Cancer
  • Chemistry
  • Genetics
  • Health Services
  • Hiv Infections
  • Medical Personnel
  • Myocardial Ischemia
  • Neoplasms
  • Patient Care
  • Surgery
  • Therapy
  • Web Browsers

Fields of Study

  • Biology

Readers

  • Clinical Trial Research.
  • Oncology and Biomarker-Based Cancer Detection.