Targeting the CRMP2-Ca2+ Channel Complex for Abortive Treatment of Migraine and Posttraumatic Headache

Abstract

Migraine is one of the worlds most common neurological disorders. Current acute migraine treatments have sub-optimal efficacy and new therapeutic options are needed. Approaches targeting calcitonin gene related peptide (CGRP) signaling are clinically effective but small molecule antagonists have not been advanced due to toxicity. In this study, we explored the axonal growth/specification collapsin response mediator protein 2 (CRMP2) as a novel druggable target for inhibiting CGRP release and for potential relevance for treatment of migraine pain and post-traumatic headache.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2017
Accession Number
AD1051168

Entities

People

  • Aubin Moutal
  • Frank Porreca
  • Jennifer Y. Xie
  • Nathan Eyde
  • Rajesh Khanna

Organizations

  • University of Arizona

Tags

DTIC Thesaurus Topics

  • Analysis Of Variance
  • Anticonvulsants
  • Brain Injuries
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Current Density
  • Depolarization
  • Drug Abuse
  • Dura Mater
  • Headache Disorders
  • Medical Personnel
  • Pain
  • Pharmacology
  • Small Molecules
  • Spiders
  • Standards

Fields of Study

  • Medicine

Readers

  • Neuroscience
  • Oncology
  • Psychological Intervention/Treatment for Stress, Anxiety, PTSD, and Related Emotional and Cognitive Health Symptoms.