Developing Software for Pharmacodynamics and Bioassay Studies
Abstract
The objective of the project is to develop a software system to process general pharmacologic, toxicological, or other biomedical research data that exhibit a non-monotonic dose-response relationship - for which the current parametric models fail. The software will analyze dose-response relationships using both monotonic and non-monotonic data. This will have significant effects on the prevention and treatment of injuries and diseases of soldiers and civilians. Military agencies, government agencies, and private sponsors will be benefited from new and improved approaches to analyze the general pharmacologic, toxicological, or other biomedical research data that exhibit a non-monotonic dose-response relationship for which the existing parametric models fail. We understand that the difference between monotonic and non-monotonic doses and responses can impact patient response and recovery. If existing and proposed methods for the study of the relationship between dose and response can be effectively implemented and compared, it will enable us to uncover important dose-response features (e.g., drug resistance or virus mutation) in response to viral infection or treatment evaluation based on experimental/clinical trial data.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2018
- Accession Number
- AD1052104
Entities
People
- Hua Liang
- Larry Liu