NAU-TGen North Dangerous Pathogens DNA Forensics Center Upgrade
Abstract
Despite its importance for infectious disease diagnosis, the ability to rapidly identify the causative agent for infections remains an elusive. Whole genome sequencing for clinical diagnostics is emerging as the future of disease identification and management by providing a rapid and highly sensitive method of diagnosing and characterizing infection. We have created a metagenomic application for analysis of clinical samples titled MetaGenomics Explorer (MetaGeniE, previously called IRIMAS)that is undergoing optimization and statistical validation with a range of different datasets. MetaGeniE provides novel insights and analyses of clinical datasets, detecting and characterizing the major component of community that is usually the infectious agent of interest as well as identifying the other microbes in this community. Furthermore, we are able to validate these detections with laboratory culture, and available patient information. Finally, we are able to take these analyses a step beyond nearly all current approaches and can use both SNP genotyping and determine features such as antibiotic resistance to precisely characterize these pathogens.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2014
- Accession Number
- AD1052106
Entities
People
- Arun Rawat
- Betty Diamond
- James Schupp
- Jeffrey T. Foster
- Paul Keim
- Rebecca E Colman
Organizations
- Northern Arizona University