Direct Test for Neuroinflammation with [11C]DPA-713-PET Scanning

Abstract

This project concerns the non-invasive detection of inflammation in the brains of individuals suffering from the Gulf War Illness (GWI). We are using quantitative positron emission tomography (PET) using [11C]DPA-713 (DPA). DPA binds to the translocator protein (TSPO), which is located on the outer mitochondrial membrane and is an established biomarker of neuroinflammation. We showed that DPA-PET was able to show a statistically significant trend of increased radiopharmaceutical binding from historical controls to Gulf War veteran controls to individuals with GWI. This pilot study lays the groundwork for a publication and larger study in this patient population. We have also added three additional historical controls and are in the process of adding them to the analysis.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2017
Accession Number
AD1052110

Entities

People

  • Martin G. Pomper
  • Robert W. Haley

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Brain
  • Brain Injuries
  • Central Nervous System
  • Data Analysis
  • Detection
  • Diagnostic Imaging
  • Imaging Techniques
  • Institutional Review Board
  • Intracellular Membranes
  • Medical Personnel
  • Neuroimaging
  • Persian Gulf Syndrome
  • Pilot Studies
  • Positron Emission Tomography
  • Positron Emissions
  • Statistical Analysis
  • Tomography

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Joint Military Operations and Doctrine.
  • Medical Imaging.