Characterization of Nanoporous as a Medium for Size-Selective Filtration, Preconcentration, and Detection of Biomolecules
Abstract
This final report summarizes the accomplishments of W911NF-09-1-0101. In particular, the following significant advances were made: (1)improved understanding and quantification of diffusion coefficients and adsorption rates of various small molecules in nanoscale porous silicon; (2) invention of straightforward nanoscale patterning technique for porous materials (patent pending); (3) demonstration of dual mode sensing platform in porous silicon; (4) first demonstration of aptasensing in nanoscale porous media and aptamer-based detection of a toxin in porous silicon; (5) demonstration of cost-effective surface enhanced Raman scattering substrate based on patterned nanoporous gold with robust understanding of enhancement mechanisms (patent pending); (6) advanced characterization of the corrosion of porous silicon upon exposure to negatively charged species; (7) first demonstration of simultaneous detection of small and large molecules using a new porous silicon Bloch surface wave sensor; (8) comprehensive characterization and demonstration of quantum dots as signal amplifiers in porous silicon sensors; (9) demonstration of sensing capability of nano- and micro-structured silicon optical structures that hold great promise for integrated sensor arrays with high detection sensitivity; and (10) fabrication of robust porous silicon membranes that allow evaluation of infiltration and binding kindetics in open-ended porous media.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 04, 2016
- Accession Number
- AD1053264
Entities
People
- Sharon M Weiss
Organizations
- Vanderbilt University