Maternal Brain-Reactive Antibodies and Autism Spectrum Disorder
Abstract
We have determined that one monoclonal antibody cloned from the memory B cell population of the mother of a child with ASD binds Caspr2. This antibody disrupts fetal brain development and leads to an ASD-like phenotype in the offspring. Forty percent of women with brain-reactive serology and a child with ASD exhibit antibodies to Caspr2; thus this antibody may contribute to approximately 5% of cases of ASD. We have also determined that the pathogenicity of anti-Caspr2 antibodies is determined, in part, by epitope specificity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2017
- Accession Number
- AD1054007
Entities
People
- Betty Diamond
Organizations
- The Feinstein Institute for Medical Research