Bisphosphonates in the Prevention of Post-Traumatic Osteoarthritis
Abstract
The following report details the final accomplishments and products with regard to the tasks (partnering-PI C. Price's responsibility) for grant PR120788P1 (Contract number: W81XWH-13-1-0147), encompassing the final reporting period from 08/01/2016 to 07/30/2017, as well as all prior reporting periods. Early, Focal Changes in Cartilage Cellularity and Structure Following Surgically-Induced Meniscal Destabilization in the Mouse Published in David, et al. 2017 J Ortho Res. - Histological analysis of mouse joints following DMM demonstrated rapid (within 3-day of injury), and focal (spatially localized) changes in both the cellularity (loss of chondrocytes) and the structural integrity of articular cartilage. The findings shed new light onto the early pathology and time-course of PTOA development following DMM and suggest that acute changes to a specific and localized population of chondrocytes may be critical in the initiation of long-term cartilage degeneration following joint injury, and represent a potential target for chondo-protective/anti-osteoarthritic therapy. Repeated Intra-Articular Injection of Zoledronic Acid Suppresses Cartilage Erosions Following Destabilization of the Medial Meniscus in Mice (David, et al. 2018 In Preparation) - The present study has shown that repeated i. a. injection of ZA into the murine knee following DMM provides cartilage protection by modulating the underlying processes of chondrocyte death, proliferation, and proteoglycan production in a spatiotemporal dependent manner. In addition to AC changes, ZA also appears to affect whole joint changes including changes in the menisci, ectopicbone, and osteophytes.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2017
- Accession Number
- AD1054304
Entities
People
- Christopher C Price
Organizations
- University of Delaware