A Closed-Loop Neural Prosthesis for Restoration of Function after Traumatic Brain Injury

Abstract

Significant progress has been made in developing activity-dependent stimulation (ADS) microdevices for use in both rodent and non-human primate (NHP) models of traumatic brain injury (TBI). A system-on-chip (SoC) for ADS has been successfully fabricated and benchtop tested for electrical functionality, and printed-circuit board (PCB) layouts of rigid-flex substrates for rodent and NHP microdevices have also been devised. Hardware, software, and firmware have also been successfully developed for wireless programming of the ADS SoC from a PC host console via a Bluetooth low energy (BLE) module, a feature that is critical for the NHP microdevices and was previously absent from our rodent microdevices. In parallel, all IACUC and ACURO regulatory approvals for animal testing have been successfully completed, and hardware/software infrastructure have been upgraded and standardized between the collaborating engineering and neurobiology teams to improve compatibility, enhance troubleshooting abilities, and increase recording capabilities.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2017
Accession Number
AD1054774

Entities

People

  • David J Guggenmos
  • Pedram Mohseni
  • Randolph J Nudo

Organizations

  • Case Western Reserve University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Brain
  • Brain Injuries
  • Circuit Boards
  • Circuits
  • Computer Programming
  • Electrical Engineering
  • Engineering
  • Failure Mode And Effect Analysis
  • Operating Systems
  • Printed Circuit Boards
  • Printed Circuits
  • Professional Development
  • Prostheses And Implants
  • Prosthetics
  • Students
  • Surgery
  • Wireless Communications

Readers

  • Clinical Trial Research.
  • Neuroscience
  • Software Engineering