Maximizing PTH Anabolic Osteoporosis Therapy

Abstract

The purpose of this study is to test the efficacy of parathyroid hormone (PTH) mono-therapy and PTH anti-catabolic combination therapies on Nmp4-/-and wild type (WT) mice. The scope of the research comprises the following specific aims: (i and ii) to determine the impact of Nmp4 on the efficacy of PTH mono- and combination therapies with various anti-catabolics in ovariectomized (ovx) mice; (iii) to determine the cell type-specific contributions to the enhanced response of the Nmp4-/- mouse to osteoporosis therapies.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2017
Accession Number
AD1054780

Entities

People

  • Joseph Bidwell

Tags

DTIC Thesaurus Topics

  • Bone And Bones
  • Bone Diseases
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Genetics
  • Health Services
  • Medical Personnel
  • Osteogenesis
  • Peptide Growth Factors
  • Proteins
  • Stem Cells

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  • Immunology and Pathology