Emergency Preservation and Resuscitation for Cardiac Arrest from Trauma (EPR CAT). Addendum

Abstract

Cardiopulmonary resuscitation (CPR) can save victims of normovolemic cardiac arrest (CA), e.g., ventricular fibrillation. During exsanguination CA from trauma, however, CPR, even with an emergency department (ED) thoracotomy and open chest CPR, results in unacceptably low survival rates. Emergency Preservation and Resuscitation (EPR) was developed to rapidly preserve the organism during ischemia, using hypothermia, drugs, and fluids, to buy time for transport and resuscitative surgery. The purpose of this study is to test the feasibility of rapidly inducing profound hypothermia (<10 degree C) with an aortic flush in trauma victims that have suffered CA and failed standard resuscitative efforts to enable resuscitative surgery and delayed resuscitation with cardiopulmonary bypass. The primary outcome variable will be survival to hospital discharge with minimal neurologic dysfunction.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2017
Accession Number
AD1055143

Entities

People

  • Patrick M. Kochanek
  • Samuel A. Tisherman

Organizations

  • University of Pittsburgh

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biomedical Research
  • Cardiac Arrest
  • Cardiac Arrhythmias
  • Cardiopulmonary Resuscitation
  • Emergencies
  • Health Services
  • Hospitals
  • Hypothermia
  • Institutional Review Board
  • Medical Personnel
  • Professional Development
  • Resuscitation
  • Standards
  • Surgery
  • Survival
  • Therapy

Fields of Study

  • Medicine

Readers

  • Cardiovascular Physiology
  • Trauma Surgery or Emergency Medicine.
  • Trauma or Military Medicine