Translational Advancement of Somatostatin Gene Delivery for Disease Modification and Cognitive Sparing in Intractable Epilepsy
Abstract
Three studies have been completed. In the first, intracranial gene transfer of a somatostatin gene believed to produce localized constitutive expression of somatostatin and neuronostatin peptides in the rat hippocampus was found capable offull reversal of a state of pathological susceptibility to intense seizures. The result extends previous work to establish that full efficacy remains possible even when the gene transfer is conducted after susceptibility to intense seizures has developed. For reasons that are remain unclear the effect appears to be all or none. A second study was undertaken to evaluate whether therapeutic efficacy of somatostatin gene delivery might derive from action on either endogenous cell proliferation in the dentate gyrus or seizure-associated inflammation reflected by activation of microglia. An initial experiment replicated previous demonstration that kindling stimulates dentate cytogenesis. A second experiment examined whether somatostatin gene delivery would alter kindling-associated cytogenesis and subsequent differentiation/survival in conjunction with seizure susceptibility.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 2017
- Accession Number
- AD1055160
Entities
People
- Michael A. King
Organizations
- University of Florida