Identification And Targeting Of Candidate Preexisting Lurker Cells That Give Rise To Castration-Resistant Prostate Cancer
Abstract
The purpose of this project is to evaluate the role of a rare subset of progenitor-like luminal cancer cells that may have special properties enabling them to resist standard therapies and mediate tumor recurrence. We determined that CD38-lo luminal cells are enriched for progenitor activity, exhibit castration-resistant features and can initiate aggressive human tumors. We found that BCL2 and PSCA are markers of CD38-lo progenitor cells, and that NFkB signaling regulates luminal progenitor activity. Finally, we determined that the CD38-lo signature and low CD38 expression are associated with poor outcome and biochemical recurrence in prostate cancer. Further understanding of these progenitor cells, the pathways they use to control their growth and survival, and the markers they uniquely express will allow us to identify and target these cells in order to predict, prevent or treat advanced castration-resistant prostate cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2017
- Accession Number
- AD1055784
Entities
People
- Andrew Goldstein
Organizations
- University of California