Metal Ion-Catalyzed Alcoholysis as a Strategy for the Destruction of Organophosphorus Chemical Warfare Agents
Abstract
Metal ion-catalyzed alcoholysis has proven to be an effective strategy for the rapid transformation of neutral reactive organophosphate esters of the phosphate, phosphonate, phosphonothioate, and phosphonothioate classes. This chemistry, using La3 (OMe)/methanol as a catalyst or solvent, which was applied to the V- and G-classes of chemical warfare agents, demonstrated extremely rapid transformation to low toxicity esters with load factors up to ~30 for nonfluoride-releasing agents. Variation of the alcohol solvent is tolerated. Variations of the metal catalyst provide potential redress to the fluoride inhibition of the class of G-agents. These observations indicate that formulations based on mixed alcohol solvents, combined with optimized metal catalysts for use in field decontamination, civilian security, and infrastructure scenarios, provide a pathway for tuning the reaction media while retaining rapid destruction kinetics.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2018
- Accession Number
- AD1055800
Entities
People
- Alexei A. Neverov
- Andrea Tamer
- Frederic J. Berg
- H. Dupont Durst
- R. S. Brown
Organizations
- Edgewood Chemical Biological Center