Effects of Corticosteroid Administration on Tongue Musculature in Rats

Abstract

Purpose: To develop interventions aimed at preventing Obstructive Sleep Apnea (OSA) incidence or manage OSA risk in asthma patients. Scope: To test the effects of orally administered inhaled Fluticasone Propionate (FP) on tongue muscle function, muscle fiber morphology and Myosin Heavy Chain (MHC) isoform expression. Major Findings: FP-treated rats, compared to placebo, displayed significant weight loss that was not entirely explained by reduced food consumption. On tongue contractile force measurements, FP-treated rats generated greater retrusive and protrusive force (expressed as percentage of maximum tetanic force generated during testing) at 40 Hz stimulation frequency, suggesting more engagement of slower-twitch fibers. Additionally, protrusive muscle endurance was elevated in FP-treated animals compared to placebo.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2018
Accession Number
AD1055814

Entities

People

  • Mihaela Teodorescu
  • Oleg Broytman

Organizations

  • University of Wisconsin System

Tags

DTIC Thesaurus Topics

  • Body Weight
  • Data Analysis
  • Digestive System Processes
  • Diseases And Disorders
  • Frequency
  • Lung Diseases
  • Measurement
  • Medical Personnel
  • Muscle Fibers
  • Muscles
  • Peripheral Nervous System
  • Propionates
  • Public Health
  • Respiration Disorders
  • Skeletal Muscle
  • Standards
  • Tissues

Fields of Study

  • Medicine

Readers

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