Mechanistic Interpretation of Hypobaria and Hyperoxia using Metabolomics and Proteomics

Abstract

The U-2 is an ultra-high reconnaissance airplane that flies as high as 70,000 ft above sea level. Both U-2 pilots and altitude chamber technicians show increased incidence of brain leukoraiosis or white matter hyperintensities (WMH) in T2 weighted magnetic resonance imaging (MRI). The incidence of WMH has been correlated to decreased cognitive function.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2017
Accession Number
AD1055941

Entities

People

  • Andrea Hoffman
  • Angela M Campo
  • Anthony M. Lowman
  • Dierdre A Mahle
  • Latha Narayanan
  • Matthew W. Grogg
  • Meghan K. Makley
  • Michael C. Moulton
  • Molly E. Chapleau
  • Nadja Grobe
  • Nicholas V. Reo
  • Pak Song
  • Sarah T. Law

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Air Force
  • Aircrafts
  • Altitude
  • Altitude Chambers
  • Brain Injuries
  • Chemistry
  • Computational Biology
  • Gene Expression
  • Liquid Chromatography
  • Magnetic Resonance
  • Magnetic Resonance Imaging
  • Mass Spectrometry
  • Metabolomics
  • Nuclear Magnetic Resonance
  • Proteins
  • Proteomics
  • Sea Level

Readers

  • Auditory Neuroscience/Auditory Physiology.
  • Oncology and Biomarker-Based Cancer Detection.
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.

Technology Areas

  • Biotechnology