Mechanism of Human Antibody Mediated Neutralization of Marburg Virus

Abstract

The mechanisms by which neutralizing antibodies inhibit Marburg virus (MARV) are not known. We isolated a panel of neutralizing antibodies from a human MARV survivor that bind to MARV glycoprotein (GP) and compete for binding to a single major antigenic site. Remarkably, several of the antibodies also bind to Ebola virus (EBOV) GP. Single-particle EM structures of antibody-GP complexes reveal that all of the neutralizing antibodies bind to MARV GP at or near the predicted region of the receptor-binding site.

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Document Details

Document Type
Technical Report
Publication Date
Feb 26, 2015
Accession Number
AD1056110

Entities

People

  • Alexander Bukreyev
  • Andrew B Ward
  • Andrew I Flayak
  • Charles D. Murin
  • Curtis Klages
  • Erica Ollmann Saphire
  • Gopal Sapparapu
  • James C. Slaughter
  • James Jr E. Crowe
  • Marnie L. Fusco
  • Phillip A Ilinykh
  • Takao Hashiguchi
  • Tania Garron
  • Thomas G. Ksiazek
  • Xiaoli Shen
  • Zachary A. Bornholdt

Organizations

  • Vanderbilt University

Tags

DTIC Thesaurus Topics

  • Animal Diseases
  • Biological Sciences
  • Blood
  • Cell Line
  • Cells
  • Chemistry
  • Ebola Virus
  • Electron Microscopy
  • Genetics
  • Indicator Dyes
  • Marburg Virus
  • Microbiology
  • Microscopy
  • Rodents
  • Viral Hemorrhagic Fevers
  • Virus Diseases
  • Viruses

Fields of Study

  • Biology

Readers

  • Missile Defense Systems.
  • Molecular and Cellular Biochemistry
  • Virology (or Medical Virology).

Technology Areas

  • Space