Reduced GABAergic Tonic Inhibition as a Shared Mechanism of Post-Traumatic Sleep Disorders And Epilepsy
Abstract
Traumatic brain injury (TBI) can lead to a wide range of sequelae including posttraumatic epilepsy (PTE). Epidemiological data suggest that as many as 20 percent of patients with TBI in the general population and up to 50 percent of patients injured in military service will develop epilepsy. There is evidence linking the severity of a TBI to the probability of developing PTE, however there still remains a large amount of uncertainty surrounding which patients will ultimately develop PTE. Thus, identifying early markers that are predictive of PTE development is imperative. Here, we performed TBI (controlled cortical impact, CCI) on 8 CD-1 mice with electroencephalogram (EEG) recordings obtained 1 week, 2 months and 3 months following surgery. Visual inspection of EEG revealed that ~30 percent of TBI animals displayed seizures, often only at later time points, where as almost all TBI animals had interictal spikes (IISs), spike clusters or trains at each time point. Therefore, nonconvulsive spikes may be a valuable predictor of later seizures but their quantitative scoring and characterization remains a major bottleneck to diagnosis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2018
- Accession Number
- AD1056224
Entities
People
- Rama Maganti