Treatment of Dengue Virus Infection with Repurposed Pharmaceuticals that Inhibit Autophagy
Abstract
Dengue virus causes untreatable viral infections that are hazardous to our armed forces. As described in the original proposal for this funding, although spautin-1 inhibits the formation of infectious dengue viral particles in cultured cells, it is toxic to mice. With the goal of finding an existing compound for repurposing against dengue virus, we collaborated with the laboratory of Vijay Pande (Stanford University), to identify compounds similar to spautin-1that had already been tested for safety in humans. A list of compounds with structural similarity to spautin-1 was identified. After testing several of these compounds for inhibition, we had obtained preliminary results that one, vandetanib, inhibited dengue growth in tissue culture.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2017
- Accession Number
- AD1056229
Entities
People
- Karla Kirkegaard
Organizations
- Stanford University