Effects of Inhaled Aerosolized Carfentanil and Subsequent Naloxone Treatment on Real-Time Physiological Responses in Mice
Abstract
This study examined the real-time exposure-response effects of aerosolized carfentanil (CRF) on opioid-induced toxicity, respiratory dynamics, and cardiac function in mice. Clinical signs of opioid-induced toxicity were observed in a dose-dependent manner during exposure and at 24 hr post-exposure to CRF. Post-exposure administration of naloxone (NX, 0.05 mg/kg, i.m.) did not increase the minute volume of animals exposed to CRF to control levels within 24 hr, but decreased clinical signs of opioid-induced toxicity and the duration of respiratory depression. This is the first study to evaluate real-time respiratory dynamics and cardiac function during exposure and up to 24 hr post-exposure to CRF. The evaluation of toxicological signs and respiratory dynamics following exposure to CRF will be useful in the development of therapeutic strategies to counteract the ongoing threat of abuse and overuse of opioids and their synthetic variants.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2018
- Accession Number
- AD1056459
Entities
People
- Alfred M. Sciuto
- Ashley Rodriguez
- Benjamin Wong
- Jennifer Devorak
- Justin Tressler
- Michael W. Perkins
Organizations
- United States Army Medical Research Institute of Chemical Defense