Therapeutic Sleep for Traumatic Brain Injury

Abstract

This proposal will test the hypothesis that correcting sleep disorders can have a therapeutic effect on Traumatic Brain Injury (TBI) The majority of TBI patients develop sleep disorders, a correlation that is extremely prevalent in military personnel. Here, we have developed a paradigm to induce TBI in Drosophila. TBI induction results in increased mortality, impaired climbing behavior, decreased/fragmented sleep, cell death and altered gene expression in glia cells, including a strong innate immune response. We are currently testing whether sleep induction can restore these impairments, following promising pilot data showing that pharmacological sleep induction after TBI increases mortality while pharmacological wake induction decreases mortality.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2018
Accession Number
AD1056812

Entities

People

  • Bart van Alphen
  • Ravi Allada

Organizations

  • Northwestern University

Tags

Communities of Interest

  • Human Systems

DTIC Thesaurus Topics

  • Brain
  • Brain Injuries
  • Cell Physiological Processes
  • Cells
  • Climbing
  • Diptera
  • Diseases And Disorders
  • Drosophila
  • Gene Expression
  • Medical Personnel
  • Military Personnel
  • Professional Development
  • Sleep Deprivation
  • Sleep Disorders

Fields of Study

  • Medicine

Readers

  • Mental Health of Military Veterans with Posttraumatic Stress Disorder (PTSD): Risk Factors, Prevalence, Symptoms, and Treatment.
  • Molecular and Cellular Biology
  • Neurotrauma and Rehabilitation Medicine.