Hyperexcitability in Sensory Circuits in Fragile X Syndrome
Abstract
Fragile X syndrome (FXS) is the most common inherited form of intellectual disability and the largest genetically identified cause of autism affecting roughly 1 in 2,500 males. One of the core deficits in autism, which is particularly prominent in FXS individuals, is the problem of hypersensitivity to a variety of sensory stimuli, which results in hyperarousal, anxiety and seizures. The underlying alterations in the development of neuronal circuits that are the basis for sensory problems in autism are not well defined. In this project the multi-PI team proposed to understand the circuit basis for altered sensory responses in the mouse model of FXS. Both in vivo imaging of neuronal activity as well as in vitro recording of individual neurons is proposed to map the connectivity and functional changes in the somatosensory cortex focusing on the role of GABAergic neurons. Furthermore a strategy to alleviate these deficits by targeting the maturation of GABAergic interneurons will be employed.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2018
- Accession Number
- AD1056834
Entities
People
- Carlos Portera-Cailliau
Organizations
- University of California, Los Angeles