Genomics of Early Lung Cancer Among Military Personnel (GELCAMP)

Abstract

Currently several biomarkers are being validated on the DECAMP specimen, but none of these use the whole genome sequencing (WGS) technology. WGS offers a novel view of mutational changes in early lung cancer. We are testing for genomic biomarkers for the detection of early lung cancer using whole genome sequencing of DNA specimens from blood, endobronchial brushings and lung tumor specimens (for those with lung cancer). While genomic testing of lung cancer has been performed in other studies, testing other sites within the lung as well as peripheral blood for these biomarkers has not been attempted. The DEAMP cohort is unique for several reasons. The DECAMP cohort is the only cohort that specifically enrolls military personnel and offers the potential to identify mutations that might be linked to military specific exposures. It is also one of the most comprehensive and detailed cohorts associated with bronchoscopic brushings and tissue matched with CT imaging, clinical history in a longitudinal cohort.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2018
Accession Number
AD1057040

Entities

People

  • Robert Browning

Organizations

  • Walter Reed National Military Medical Center

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Biological Markers
  • Biology
  • Biomedical Research
  • Cancer
  • Data Analysis
  • Department Of Defense
  • Detection
  • Electronic Mail
  • Genomics
  • Lung Cancer
  • Medical Personnel
  • Military Medicine
  • Military Personnel
  • Mutations
  • Neoplasms
  • Universities

Fields of Study

  • Biology

Readers

  • Immunology and Pathology
  • Molecular and genetic basis of cancer.