Pharmacology of Polycystic Kidney Disease Proteins

Abstract

The primary goal of this proposal is to identify regulators, in particular activators, of PKD1 and PKD2 proteins for future pharmacological dissection of their structures and functions that will shed light on pathogenesis of ADPKD. Aim 1: Identify small molecule activators of PKD proteins by liposome flux assay. Aim 2: Identify cone snail peptide regulators of PKD proteins. Aim 3: Generate conformation-sensitive, functional antibodies for PKD proteins.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2018
Accession Number
AD1057494

Entities

People

  • Erhu Cao

Organizations

  • University of Utah

Tags

DTIC Thesaurus Topics

  • Antibodies
  • Biomedical Research
  • Chemical Compounds
  • Department Of Defense
  • Diseases And Disorders
  • Kidney Diseases
  • Lipids
  • Mass Spectrometry
  • Molecules
  • Pathogenesis
  • Pharmacology
  • Proteins
  • Regulators
  • Small Molecules
  • Synthetic Membranes
  • Throughput

Fields of Study

  • Biology
  • Chemistry

Readers

  • Molecular and Cellular Biochemistry
  • Molecular and Cellular Biology