Zika Virus Persistence in Immune-Priviledged Organs

Abstract

This project involves the study of Zika virus (ZIKV) persistence within immune privileged organs including the testes and eyes. We set out to understand the role of adaptive immunity (e.g., B cells and T cells) as well as interferon regulatory factors (IRF3, IRF5, and IRF7) in controlling ZIKV persistence within immune-privileged organs. During this research period, we discovered that absence of humoral and cellular immune responses results in increased persistence of ZIKV in these organs. Additionally, our initial experiments indicate that interferon regulatory factors, and especially IRF7, also prevents ZIKV persistence in the eye and testes.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2018
Accession Number
AD1057500

Entities

People

  • Jonathan Miner

Organizations

  • University of Washington

Tags

DTIC Thesaurus Topics

  • Adaptive Immunity
  • Biomedical Research
  • Cells
  • Electronic Mail
  • Immunity
  • Infection
  • Interferon
  • Lymphocytes
  • Professional Development
  • Proteins
  • Technology Transfer
  • Therapy
  • Viruses
  • Wound Infections
  • Zika Virus

Fields of Study

  • Medicine

Readers

  • Immunology
  • Immunology and Pathology
  • Virology (or Medical Virology).