Genome Sequencing to Enable a Model Salamander for Tissue Regeneration Research
Abstract
Salamanders are important vertebrate model organisms in regenerative medicine. In this application, we proposed to enhance research resources for the Mexican axolotl (Ambystoma mexicanum) by innovating an approach to sequence their large 32,000,000,000 base pair genome. We successfully developed methods to isolate and sequence whole axolotl chromosomes, and published a manuscript in a leading journal that describes our approach and initial characterization of the axolotl genome. Thus, we accomplished the objectives of our project, laying the ground work for developing a full axolotl genome assembly.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 06, 2016
- Accession Number
- AD1057905
Entities
People
- S. Randal Voss
Organizations
- University of Kentucky