Glatiramer Acetate (Copaxone) Treatment of Noise-Induced Hearing Loss
Abstract
The primary purpose of the project was to test a novel pharmaceutical treatment strategy involving a drug that has been shown to protect neural tissues from injury by blocking the degenerative outcomes of inflammation. The compound in question is glatiramer acetate (GA), a chemical that modulates the immune response to inflammation and diminishes associated pathology. The rationale underlying this project is that exposure to intense sound causes inner ear inflammation, and synaptopathy. Treatment of mice with GA alone, or in combination with anti-inflammatory drugs protected against noise-induced haring loss and synaptopathy.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 26, 2018
- Accession Number
- AD1057956
Entities
People
- Dominic E. Cosgrove