Toxin-Antitoxin Systems in Clinical Pathogens

Abstract

Toxin-antitoxin (TA) systems are prevalent in bacteria and archaea. Although not essential for normal cell growth, TA systems are implicated in multiple cellular functions associated with survival under stress conditions. Clinical strains of bacteria are currently causing major human health problems as a result of their multidrug resistance, persistence and strong pathogenicity. Here, we present a review of the TA systems described to date and their biological role in human pathogens belonging to the ESKAPE group (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp.) and others of clinical relevance (Escherichia coli, Burkholderia spp., Streptococcus spp. and Mycobacterium tuberculosis). Better understanding of the mechanisms of action of TA systems will enable the development of new lines of treatment for infections caused by the above-mentioned pathogens.

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Document Details

Document Type
Technical Report
Publication Date
Jul 20, 2016
Accession Number
AD1057964

Entities

People

  • German Bou
  • Laura Fernandez-garcia
  • Lucia Blasco
  • Maria Lopez
  • María Tomás
  • Rodolfo García-contreras
  • Thomas E Wood

Tags

DTIC Thesaurus Topics

  • Anti-Bacterial Agents
  • Bacteria
  • Bacterial Infections
  • Cells
  • Chemistry
  • Chromosomes
  • Genetics
  • Health Services
  • Infection
  • Infectious Diseases
  • Microbial Genetics
  • Microbiology
  • Microbiomes
  • Mycobacterium Tuberculosis
  • Pathogenic Bacteria
  • Wound Infections
  • Wounds And Injuries

Fields of Study

  • Biology

Readers

  • Microbial Pathology
  • Team-Based Human-Centered Cognitive Task Decision Making and Information Performance.