Commentary: What Is the Link between Stringent Response, Endoribonuclease Encoding Type II Toxin-Antitoxin Systems and Persistence
Abstract
In a recent paper published in Frontiers in Microbiology, Ramisetty et al. (2016) questioned the mainstream model regarding bacterial persistence proposed by the group of K. Gerdes (Maisonneuve et al., 2011, 2013). Persistence is an important phenomenon thought to contribute to infectious diseases chronicity and antibiotic resistance selection (Michiels et al., 2016). This reversible and low frequency phenotypic switch allows bacteria to enter a particular physiological state in which they can sustain the presence of a given antibiotic (Kaldalu et al., 2016;Wood, 2016).
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 14, 2017
- Accession Number
- AD1057984
Entities
People
- Laurence V. Melderen
- Thomas K. Wood