The Role of Mesothelial Omentin in Ovarian Cancer Progression

Abstract

We hypothesize that omentin (ITLN1) suppresses ovarian cancer progression by sequestering lactoferrin from its receptor on the ovarian cancer cells and adipocytes, and that lactoferrin promotes ovarian cancer cells motility and growth. A majority of experiments proposed under Major goal 1 and 5, and subsets experiments proposed in Major goal 2, 6 have been accomplished. Our results demonstrated that lactoferrin triggers intracellular Ca(exp 2+) mobilization, enhances the amplitude of cellular traction exerted on substratum, and increases expression of matrix metalloproteinase-1 (MMP1) in ovarian cancer cells. We also showed that omentin could counteract the stimulating effects of lactoferrin on ovarian cancer cells. For Major goal 8, we have been successful to boost the circulating omentin levels in C57BL/6 mice using adeno-associated virus.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2018
Accession Number
AD1058223

Entities

People

  • Kay-Pong Yip

Organizations

  • University of South Florida

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Adipose Tissue
  • Amplitude
  • Biomedical Research
  • Cancer
  • Cell Line
  • Cells
  • Culture Techniques
  • Fat Cells
  • Gene Therapy
  • Genes
  • Medical Personnel
  • Mobilization
  • Neoplasms
  • Ovarian Cancer
  • Pcr Testing
  • Professional Development
  • Traction

Fields of Study

  • Biology

Readers

  • Oncology (Cancer Research).