Causal Analysis of Rule-Based Models of Signalling Pathways

Abstract

When a cell receives a signal from its environment through a membrane receptor, a cascade of internal reactions is triggered which leads ultimately to its response, usually a change in its metabolism, its ability to divide, or in the expression level of a gene. Many diseases including some forms of cancer are related to some defects in these signalling pathways. Such biological systems usually feature thousands of proteins interacting in a highly concurrent way and their complexity makes modelling necessary to the development of better biocuration techniques.

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Document Details

Document Type
Technical Report
Publication Date
Aug 24, 2017
Accession Number
AD1058532

Entities

People

  • Jonathan Laurent

Organizations

  • Harvard Medical School

Tags

Communities of Interest

  • Biomedical
  • Engineered Resilient Systems

DTIC Thesaurus Topics

  • Abstracts
  • Algorithms
  • Chemical Reactions
  • Coding
  • Compression
  • Computer Science
  • Data Compression
  • Differential Equations
  • Enzymes
  • Equations
  • Kinetics
  • Language
  • Phosphorylation
  • Protein-Protein Interactions
  • Side Effects
  • Simulations
  • Simulators

Fields of Study

  • Biology

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