Developing Novel PepT1-Targeted Modulators for Inflammatory Bowel Disease (IBD) Therapy
Abstract
The overarching research goal of this project is to contribute to the understanding of inflammatory bowel disease (IBD) mechanisms by providing an integrated experimental and computational description of substrate specificity in the human Proton-coupled oligopeptide transporter, PepT1 (SLC15A1). The methodologies include structure based drug discovery computations, combined with cell-based and in vivo models of IBD. During the past year, we have made significant progress toward completing our Project Goals. We have continued to characterize structure function relationships in PepT1.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2017
- Accession Number
- AD1059190
Entities
People
- Avner Schlessinger
- David E. Smith
Organizations
- Icahn School of Medicine at Mount Sinai