Mechanisms of Gastrointestinal Neuropeptide Signaling in an Animal Model of SCI Following Weight Loss Surgery
Abstract
Approximately two-thirds of spinal cord injured (SCI) individuals become overweight or obese. The greatest increase from normal to overweight or obese has been reported to occur during the first year after acute rehabilitation. In addition to limiting self-help techniques (e.g., wheelchair transfer) these individuals are susceptible to obesity-related conditions including Type II diabetes. As the life-span of SCI individuals continues to increase, these chronic conditions diminish the quality of life while increasing the financial healthcare burden for veterans with SCI. Weight loss surgery (WLS), including sleeve gastrectomy (SG) and the Roux-en-Y gastric bypass (RYGB) surgery, is regarded as highly effective in the long-term treatment of obesity and remission of type 2 diabetes. The weight-reduction after WLS does not appear to reflect mechanical restriction of food intake or malabsorption of nutrients, but a change in the regulatory signaling within the gut-brain axis. Examples of these changes include the increased release of anorexigenic gut hormones such as glucagon-like peptide-1 (GLP-1) and alterations in gastrointestinal transit.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2018
- Accession Number
- AD1059196
Entities
People
- Andras Hajnal
- Gregory Holmes
Organizations
- Pennsylvania State University