Histopathology Results for Acute and Two-Week Inhalation Toxicity Studies with Polyalphaolefin (PAO) Fluid in Rats
Abstract
Polyalphaolefin (PAO) fluids are being utilized as heat sink coolants for aircraft service air and electronic components. Available literature studies for PAO are inadequate to set exposure limits. An acute inhalation study examining the toxicity of PAO fluid in male and female Fischer 344 rats(0, 100, 500 and 1000 mg/m3 aerosol for 6 hours) resulted in the 500 and 1000 mg/m3 exposed rats displaying lethargy. Decreases in food and water consumption resulted in decreased body weights and skewed organ to body weight ratios in the 500 and 1000 mg/m3 acute exposure groups. A 14-day recovery cohort indicated that these effects did not persist after 24 hours. A repeated inhalation study with 0, 20, 100 and 300 mg/m3 PAOaerosol (6 hours/day, 5 days/week, 2 weeks) showed no significant effects.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 30, 2018
- Accession Number
- AD1059948
Entities
People
- Brian A. Wong
- David R. Mattie
- Karen L. Mumy
- Matthew D. Wegner
- Teresa R Sterner