CDCA7L and Mechanisms of Increased Male Bias in Glioma
Abstract
We are proposing to study CDCA7L in an NF1 mutant model of astrocytoma and glioblastoma and in neurotransmitter levels in NF1 mutant brains, comparing males and females. The results of his work can be used to develop additional hypotheses on whether a "yin-yang" relationship exists in males and females between risk for brain cancer and risk for depression, or other earning and social dysfunctions. Developing new treatments for gliomas and learning/social dysfunction through a better understanding of the basic biology will benefit both male and female NF1 patients in the long term.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2018
- Accession Number
- AD1060273
Entities
People
- Karlyne Reilly
Organizations
- Geneva Foundation