Application of Combined Cardioprotective Agents to Preserve Organ Function and Improve Survival during Experimental Hemorrhagic Shock
Abstract
We compared the effects of different anesthesia regimen (with either intraperitoneal ketamine/xylazine or with isoflurane) on the survival rate at 6 weeks after hemorrhagic shock in rats, and determined the survival rates of rats that were subjected to 30 mmHg of hypotension for 10, 20, 30, 35, 45, or 60 minutes after hemorrhagic shock. The results showed that there was a 25.6 % survival rate in rats that were anesthetized with ketamine/xylazine and were subjected to 30 mmHg of hypotension for 30 minutes. Therefore we use this setting as hemorrhagic shock model for the further studies. We demonstrated that remote ischemic preconditioning improved recovery of blood pressure and maintained more circulating intravascular blood volume in the early phase of resuscitation, improved BUN, and markedly and significantly improved short and long term survival in rats subjected to hemorrhagic shock. However, mitochondrial protective agent SBT-0100-05 did not affect blood pressure and cardiac function during hemorrhagic shock and acute resuscitation phase, and did not improve long term survival in rats subjected to hemorrhagic shock.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2018
- Accession Number
- AD1060280
Entities
People
- Robert A Kloner
Organizations
- Huntington Medical Research Institutes