A new paradigm for radiation induced persistent cellular stress and genomic instability in lung carcinogenesis

Abstract

We study cellular stress responses to sublethal doses of 1 or 2 Gy X Rays that persist for up to a week in cultures of an immortalized normal bronchial epithelial cell line, HBEC3KT. We have found that p38MAPK is a driver and genomic instability and cell transformation an outcome of these responses, thus potentially involved in the development of radiogenic cancer. Further studies into these responses revealed altered levels of ubiquitination associated to chromatin, which can be modulated by interfering with p38MAPKactivity.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2018
Accession Number
AD1060283

Entities

People

  • Erica Werner

Organizations

  • Emory University

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Cancer
  • Cell Division
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Chromosome Structures
  • Chromosomes
  • Culture Techniques
  • Data Analysis
  • Energy Transfer
  • Epithelial Cells
  • Genetics
  • Genomic Instability
  • Inhibitors
  • Instability
  • Ionizing Radiation
  • Medical Personnel
  • Neoplasms
  • Proteins
  • Radiation
  • Radiotherapy
  • Stem Cells
  • Stress (Physiology)
  • Students
  • Therapy
  • X Rays

Fields of Study

  • Biology

Readers

  • Molecular Biology and Genetics
  • Nuclear and Radiation Engineering.
  • Psychological Intervention/Treatment for Stress, Anxiety, PTSD, and Related Emotional and Cognitive Health Symptoms.