Molecular Mechanisms of Transcription Factor Dosage in Heart Development and Congenital Heart Disease
Abstract
We have discovered that we can indeed understand molecular mechanisms of Congenital Heart Disease using cultured pluripotent stem cells when differentiated to cardiac cells. This requires the study of thousands of single cells rather than the whole population. These results will help us understand what type of cell is most affected upon loss of the congenital heart disease gene TBX5. Our findings in mice are also pointing a specific cell type within the developing heart that is most relevant to congenital heart disease.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2018
- Accession Number
- AD1060297
Entities
People
- Benoit Bruneau